Luhan Pharmachem Co., Lt
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Country: 
China (Mainland)
Business Type:Lab/Research institutions
Tel: +86-871-65110906
Mobile: 86-131 6530761
Tel: +86-871-65110906
Fax:
Province/state: Yunnan
City: Kunming
Street: Room702, Building 2, 365 Dianchi Road, Kunming, Yunnan Province, P.R. China
MaxCard:
Pentalamide ethanol(544-31-0)
Information
Pentaylamide ethanol (PEA) is an endogenous fatty acid amide, which belongs to the category of nuclear transcription factor agonists. PEA has been proven to bind to nuclear receptors (peroxisome proliferator-activated receptor α, PPAR-α) in the nucleus, and has an impact on a variety of chronic pain and inflammation-related biological functions. It is a natural Anti-inflammatory agent.
Quality
Advanced technology
Supper quality
Effective & safety package
Service
Professional and timely afte-sale service(replied within 12h)
COMPANY INFORMATION
Jinan Kangcheng Pharmaceutical Technology Co., Ltd.
Add:Jinan Area,China(Shandong) Pilot Free Trade Zone,China
The company focuses on the development and transfer of pharmaceutical technology. It is a modern enterprise integrating technology development, transfer and sales of APIs, pharmaceutical intermediates, and nutraceutical raw materials.
The company adheres to the principle of integrity and innovation, and provides customers with professional products and advanced technical services.
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PALMITOYLETHANOLAMIDE |
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Product information |
English Name：palmitoylethanolamide |
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English Alias：(Hydroxyethyl)palmitamide;2-(Palmitoylamino)ethanol;2-Palmitamidoethanol;AM 3112; |
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Chinaese Name：十六酰胺乙醇（PEA） |
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Chianese Alias：帕米醇、棕榈酰乙醇、棕榈酰胺 MEA |
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CAS号：544-31-0 |
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Formula：C18H37NO2 |
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Molecular weight:299.49 |
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Appearance：White crystal or crystalline powder. |
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Purity：98.0% |
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Use&Pharmacology |
Pentaylamide ethanol (PEA) is an endogenous fatty acid amide, which belongs to the category of nuclear transcription factor agonists. It has been proven to bind to nuclear receptors (peroxisome proliferator-activated receptor α, PPAR-α), and affect a variety of biological functions related to chronic pain and inflammation. It is a natural anti-inflammatory agent. Inflammatory agent. PEA has been shown to have anti-inflammatory, anti-infective damage, neuroprotective, and anticonvulsant properties. PEA has been exploring people's various pain states in different clinical trials for inflammation and pain syndromes. PEA can effectively prevent rat cerebellar granule cells from glutamate toxicity and enhance the motility of microglia. In the mitochondrial fragments of cells stimulated by PEA, the expression of rapid steroid synthesis regulator protein (StAR) and P450scc increased, which include some neurosteroid-forming proteins. PEA also has a protective effect: for example, it reduces the formation of malondialdehyde in cells that have treated L-buthionine-(S,R)-sulfoximine that causes glutathione deficiency. The effect of PEA can be partially inhibited by finasteride (5a-reductase inhibitor). PEA attenuates the inflammatory response in wild-type mice, but has no effect on PPAR-α-deficient mice. PEA can inhibit peripheral inflammation, degranulation of mast cells, and exert neuroprotective and analgesic effects in mice and rats. At the same time, the production of ChemicalbookNO, the influx of neutrophils, and the expression of pro-inflammatory proteins such as inducible nitric oxide synthase and cyclooxygenase 2 have changed. In addition, PEA can regulate many physiological processes, including pain perception, convulsions, and neurotoxicity. This product is an organic synthesis intermediate and pharmaceutical intermediate, which can be used in the laboratory research and development process and the chemical medicine research and development process. |
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Package&Storage |
Package：1kg/bag, 10kg/drum, 25kg/drum (on request) |
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Storage&Validity：Cool, shading, dry and sealed/2years |
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